Cloperastine hydrochloride

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1m g/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwit houtaffectingPRintervalorQRSwidth.Cloperastinehydrochlorideshowsrelati velylowacutetoxicChemicalbookitywhenadministeredbytheintraperitonealro uteinratsandmice,and showsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizoa te,theLD50inratsandmiceforthetwoadministrationrouteceeds1000and2000mg/ kg,respectively.

Brand: Soarwin

CAS No.: 14984-68-0

EC Number: 239-067-8

Molecular Formula: C20H25Cl2NO

Melting point: 147.9°